The purpose of this study was to analyze the effect of using digital comics by means of ToonDoo for enhancing English as a Foreign Language (EFL) vocabulary learning. A quasi-experimental approach was applied, and the participants included 189 private high school students, who were divided into control (105) and experimental (84) group. The data for this research was gathered through pre and post-tests, a post-questionnaire, and an observation sheet. This data was analyzed quantitatively and qualitatively and demonstrated that students had a positive perception on the use of ToonDoo for learning EFL vocabulary, resulting in an improvement of their academic performance.